Closed production is a key production mode for pharmaceutical companies to improve product safety. The design of closed equipment is a risk-based solution. 

Equipment manufacturers need to conduct a preliminary analysis of key and potential risks for the process and plant conditions required for the drug, such as regulations, 

layout, and industrial objectives.

According to the industry, closed production can increase production efficiency, save energy, save investment, and comply withGMP requirements, such as preventing 

various pollutions that may be caused by drugs during production and damage to the environment and human health.

With the continuous improvement of the requirements of the domestic pharmaceutical industry and the continuous development of the pharmaceutical industry, 

the closed production mode has become more and more popular, and the closed equipment market has also ushered in good development opportunities.

However, there are still technical defects in the current domestic closed equipment. In some developed countries in the West, in the process of mixing, granulating, 

drying, etc. in solid preparations, the equipment for its development and application of closed production and multi-functional technology has good performance. 

The operators only need to use airflow to add raw and auxiliary particles to the hopper and management. The tableting operation can be done in the control room 

via a management computer and control panel.

Therefore, in the face of the gap, there is still a lot of room for development in China's closed equipment, and manufacturers have both opportunities and challenges.

According to the industry, according to the concept of quality from design, airtightness should be part of the design of high-activitydrug production process equipment. 

In the case of ensuring strict sealing of the incoming and outgoing materials, it is also necessary to consider the release of the cavity pressure and the circulation of 

the internal airflow. The material loading adopts a closed vacuum conveying mode to meet the requirements of dust-free, continuous and sealed standards.

At the same time, some domestic manufacturers have introduced various types of high-closed solid preparation lines to meet market needs.For example, there are 

manufacturers of closed capsule filling machines with higher capacity than general capsule filling machines, and multiple measuring stations can be installed to 

achieve different types of drug filling in the same capsule. The equipment has a flexible and mixed filling mode, which can realize the mixing and filling of a variety 

of materials. In addition to meeting the standardized measurement combination, the company can also develop a special hybrid filling mode according to the 

requirements of users.

The manufacturer said that in order to achieve closed production, the capsule filling machine uses high-active powder to seal the feed, and the sealed cavity adopts 

an inflatable sealing ring, and does not deflate after the power is cut off, ensuring complete sealing andisolation of the production area.

In the production process, the purified air passing through the high-efficiency filter of the junior high school is sent to the inside of the host by the blower, and the 

exhaust air is filtered by the high-efficiency filter through the dust collector and the bag, and then discharged to the outside by the exhaust fan.

In addition, all parts that come into contact with the product can be analyzed for operational risk control prior to dismantling, or more stringent and more complex 

online cleaning to prevent cross-contamination problems.

In general, as China's regulation of drug quality and safety is more stringent, closed production has become an important production mode to ensure product safety 

and pollution. Therefore, the sealed device will have a large room for development. However, domestic pharmaceutical equipment companies need to learn from 

foreign precision equipment manufacturers in terms of equipment's airtight design, and there is still room for improvement in terms of equipment flexibility.